Commensal bacteria modulate the tumor microenvironment
نویسندگان
چکیده
منابع مشابه
MicroRNA Targeting to Modulate Tumor Microenvironment
Communication between stromal cells and tumor cells initiates tumor growth, angiogenesis, invasion, and metastasis. Stromal cells include cancer-associated fibroblasts, tumor-associated macrophages, pericytes, endothelial cells, and infiltrating immune cells. MicroRNAs (miRNAs) in the tumor microenvironment have emerged as key players involved in the development of cancer and its progression. m...
متن کاملEditorial: Novel Targets and Targeting Technologies to Modulate Tumor Microenvironment
In recent years, there is an increasing attention on the impact of the tumor microenvironment (TME) on tumor initiation, progression, and metastasis (1). Malignant tumor cells and non-malignant stromal cells actively interact with each other and thereby create a tumor-supportive microenviron-ment (2). TME is composed of extracellular matrix and several cell types, such as cancer-associated fibr...
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In healthy subjects, the intestinal microbiota interacts with the host's epithelium, regulating gene expression to the benefit of both, host and microbiota. The underlying mechanisms remain poorly understood, however. Although many gut bacteria are not yet cultured, constantly growing culture collections have been established. We selected 57 representative commensal bacterial strains to study b...
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The resident prokaryotic microflora of the mammalian intestine influences diverse homeostatic functions of the gut, including regulation of cellular growth and immune responses; however, it is unknown how commensal prokaryotic organisms mechanistically influence eukaryotic signaling networks. We have shown that bacterial coculture with intestinal epithelial cells modulates ubiquitin-mediated de...
متن کاملCommensal ocular bacteria degrade mucins.
BACKGROUND/AIMS Antimicrobial activity in tears prevents infection while maintaining a commensal bacterial population. The relation between mucin and commensal bacteria was assessed to determine whether commensals possess mucinolytic activity, how degradation depends on mucin integrity, and whether mucins affect bacterial replication. METHODS Bacteria were sampled from healthy eyes and contac...
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ژورنال
عنوان ژورنال: Cancer Letters
سال: 2016
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2015.12.028